Article
Detailed molecular analysis of 1p36 in neuroblastoma.
Medical and pediatric oncology - 1 Jan 2001
White P S, Thompson P M, Seifried B A, Sulman E P, Jensen S J, Guo C, Maris J M, Hogarty M D, Allen C, Biegel J A, Matise T C, Gregory S G, Reynolds C P, Brodeur G M
Abstract excerpt
BACKGROUND: Several lines of evidence es tablish that chromosome band 1p36 is frequently deleted in neuroblastoma primary tumors and cell lines, suggesting that a tumor suppressor gene within this region is involved in the development of this tumor. PROCEDURE: We analyzed the status of 1p36 in primary neuroblastomas and cell lines to define the region of consistent rearrangement. RESULTS: Loss of heterozygosity...
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