Article
Expression and sequence analysis of candidates for the 1p36.31 tumor suppressor gene deleted in neuroblastomas.
Oncogene - 31 Jan 2008
Okawa E R, Gotoh T, Manne J, Igarashi J, Fujita T, Silverman K A, Xhao H, Mosse Y P, White P S, Brodeur G M
Abstract excerpt
Neuroblastomas are characterized by 1p deletions, suggesting that a tumor suppressor gene (TSG) resides in this region. We have mapped the smallest region of deletion (SRD) to a 2 Mb region of 1p36.31 using microsatellite and single nucleotide polymorphisms. We have identified 23 genes in this region, and we have analysed these genes for mutations and RNA expression patterns to identify candidate TSGs. We...
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