Article
Identification of a 1-megabase consensus region of deletion at 1p36.3 in primary neuroblastomas.
Medical and pediatric oncology - 1 Dec 2000
Hogarty M D, Liu X, Guo C, Thompson P M, Weiss M J, White P S, Sulman E P, Brodeur G M, Maris J M
Abstract excerpt
BACKGROUND: Deletion of the distal short arm of chromosome 1 occurs frequently in neuroblastoma. In addition, neuroblastoma has been described in children with constitutional deletions within 1p36, supporting the existence of one or more neuroblastoma suppressor genes within this region. PROCEDURE: We have pursued a 1p36 tumor suppressor gene identification strategy that has included deletion mapping of 566...
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