Article
A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme.
Development (Cambridge, England) - 1 Aug 1998
Thomas T, Kurihara H, Yamagishi H, Kurihara Y, Yazaki Y, Olson E N, Srivastava D
Abstract excerpt
Numerous human syndromes are the result of abnormal cranial neural crest development. One group of such defects, referred to as CATCH-22 (cardiac defects, abnormal facies, thymic hypoplasia, cleft palate, hypocalcemia, associated with chromosome 22 microdeletion) syndrome, exhibit craniofacial an...
Topics
- Animals
- Apoptosis
- Basic Helix-Loop-Helix Transcription Factors
- Branchial Region
- DNA-Binding Proteins
- Down-Regulation
- Endothelin-1
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Helix-Loop-Helix Motifs
- Histocytochemistry
- Homeodomain Proteins
- In Situ Hybridization
- MSX1 Transcription Factor