Article
Recombinase-mediated cassette exchange reveals the selective use of Gq/G11-dependent and -independent endothelin 1/endothelin type A receptor signaling in pharyngeal arch development.
Development (Cambridge, England) - 1 Feb 2008
Sato Takahiro, Kawamura Yumiko, Asai Rieko, Amano Tomokazu, Uchijima Yasunobu, Dettlaff-Swiercz Dagmara A, Offermanns Stefan, Kurihara Yukiko, Kurihara Hiroki
Abstract excerpt
The endothelin (Edn) system comprises three ligands (Edn1, Edn2 and Edn3) and their G-protein-coupled type A (Ednra) and type B (Ednrb) receptors. During embryogenesis, the Edn1/Ednra signaling is thought to regulate the dorsoventral axis patterning of pharyngeal arches via Dlx5/Dlx6 upregulation. To further clarify the underlying mechanism, we have established mice in which gene cassettes can be efficiently...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.