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Article

Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Sept 2003

Morishima Masae, Yanagisawa Hiromi, Yanagisawa Masashi, Baldini Antonio

Abstract excerpt

Pharyngeal arch artery (PAA) remodeling defects account for several cases of congenital heart disease. Mutations in the Endothelin-1 genetic pathway or Tbx1, a candidate gene for DiGeorge syndrome, cause similar aortic arch defects. Previous research suggests that Tbx1 may trigger diffusible signals from the pharyngeal arches to support the growth of the PAAs that contribute to the mature aortic arch. The...

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Source

Identifiers

PMID: 12950083
DOI: 10.1002/dvdy.10358

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis.PMID 12950083Read ↗

Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants.Semantic proximity Read ↗

Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways.Semantic proximity Read ↗

DiGeorge syndrome: an update.Semantic proximity Read ↗

Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesisSemantic proximity Read ↗

Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract.Semantic proximity Read ↗

Development of the human aortic arch system captured in an interactive three‐dimensional reference modelSemantic proximity Read ↗

22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development.Semantic proximity Read ↗

<i>Tbx1</i>expression in pharyngeal epithelia is necessary for pharyngeal arch artery developmentSemantic proximity Read ↗

<i>Pax9</i> is required for cardiovascular development and interacts with <i>Tbx1</i> in the pharyngeal endoderm to control 4 <sup>th</sup> pharyngeal arch artery morphogenesisSemantic proximity Read ↗

Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling.Semantic proximity Read ↗

Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy.Semantic proximity Read ↗

Tbx1 haploinsufficiency in the DiGeorge syndrome region causes aortic arch defects in miceSemantic proximity Read ↗

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