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Article

C-terminal region of protein kinase CK2 alpha: How the structure can affect function and stability of the catalytic subunit.

Journal of cellular biochemistry - 15 May 2004

Grasselli Elena, Tomati Valeria, Bernasconi Marco V, Nicolini Claudio, Vergani Laura

Abstract excerpt

A novel mutant of the catalytic alpha subunit of human protein kinase CK2 (CK2 alpha) was designed in an attempt to clarify the role of the carboxylic-terminal segment characteristic of vertebrates, excluding fish. Starting from the sequence alignments, we constructed a phylogenetic tree of the primary structure of CK2 alpha. On this basis, we substituted two distal prolines with alanines (PA 382-384)....

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PMID: 15108354
DOI: 10.1002/jcb.20049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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