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Article

Evidence that the amino acid residue P272 of arginine kinase is involved in its activity, structure and stability.

International journal of biological macromolecules - 1 Nov 2008

Wu Qing-Yun, Li Feng, Wang Xiao-Yun

Abstract excerpt

In this research, the role of amino acid residue P272 of arginine kinase (AK) was investigated by site-directed mutagenesis. When the structure of AK was impaired by mutation, AK was in a partially unfolded state with more hydrophobic exposure, which was prone to aggregate under environmental stresses. Mutation at this position influences transition from the molten globule intermediate to the native state in...

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Identifiers

PMID: 18703083
DOI: 10.1016/j.ijbiomac.2008.07.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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