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Article

Generation of mutants of CK2alpha which are dependent on the beta-subunit for catalytic activity.

Molecular and cellular biochemistry - 1 Nov 2001

Sarno S, Ghisellini P, Cesaro L, Battistutta R, Pinna L A

Abstract excerpt

To shed light on the structural features underlying high constitutive activity of protein kinase CK2 a number of mutants of the human CK2alpha-subunit altered in the interactions between the N-terminal segment and the activation loop have been generated and shown to be defective in catalytic activity. In particular the truncated mutant delta2-12 displays under standard conditions an almost complete loss of...

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PMID: 11827164

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