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Article

Drosophila protein kinase CK2 is rendered temperature-sensitive by mutations of highly conserved residues flanking the activation segment.

Molecular and cellular biochemistry - 1 Mar 2009

Kuntamalla Pallavi P, Kunttas-Tatli Ezgi, Karandikar Umesh, Bishop Clifton P, Bidwai Ashok P

Abstract excerpt

CK2 is a Ser/Thr protein kinase essential for animal development. Although null alleles for CK2 are available in the mouse and Drosophila models, they are lethal when homozygous, thus necessitating conditional alleles for analysis of its developmental roles. We describe the isolation of temperature-sensitive (ts) alleles of Drosophila CK2alpha (dCK2alpha). These alleles efficiently rescue lethality of yeast...

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Identifiers

PMID: 19039653
DOI: 10.1007/s11010-008-9963-6
PMCID: PMC2777608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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