Article
Catalytic activity of mutants of yeast protein kinase CK2alpha.
Acta biochimica Polonica - 1 Jan 2008
Sajnaga Ewa, Kubiński Konrad, Szyszka Ryszard
Abstract excerpt
Yeast CK2 is a highly conserved member of the protein kinase CGMC subfamily composed of two catalytic (alpha and alpha') and two regulatory (beta and beta') subunits. The amino-acid sequences of both catalytic subunits are only 60% homologous. Modelling of the tertiary structure of the CK2alpha displays additional alpha-helical structures not present in the CK2alpha' subunit, connecting the ATP-binding loop with...
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