Article
The role of the N-terminal domain in the regulation of the "constitutively active" conformation of protein kinase CK2α: insight from a molecular dynamics investigation.
ChemMedChem - 4 Jul 2011
Cristiani Andrea, Costa Giorgio, Cozza Giorgio, Meggio Flavio, Scapozza Leonardo, Moro Stefano
Abstract excerpt
Protein kinase CK2 is an extremely well-conserved pleiotropic protein kinase with a growing list of substrates, the majority of which are proteins implicated in signal transduction, gene expression, and transcription-related functions. Protein kinase CK2 is a ubiquitous heterotetrameric serine/threonine protein kinase made up of two α or α' catalytic subunits and two β regulatory subunits. Moreover, protein...
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