Article
Basic residues in the 74-83 and 191-198 segments of protein kinase CK2 catalytic subunit are implicated in negative but not in positive regulation by the beta-subunit.
European journal of biochemistry - 1 Sept 1997
Sarno S, Vaglio P, Marin O, Meggio F, Issinger O G, Pinna L A
Abstract excerpt
Protein kinase CK2 is a ubiquitous pleiotropic serine/threonine protein kinase whose holoenzyme is comprised of two catalytic (alpha and/or alpha') and two non-catalytic, beta-subunits. The beta-subunit possesses antagonist functions that can be physically dissected by generating synthetic fragme...
Topics
- Amino Acid Sequence
- Binding Sites
- Calmodulin
- Casein Kinase II
- Down-Regulation
- Enzyme Activation
- Heparin
- Molecular Sequence Data
- Mutation
- Peptide Fragments
- Phosphorylation
- Protein Serine-Threonine Kinases