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Article

Structure of the human protein kinase CK2 catalytic subunit CK2α' and interaction thermodynamics with the regulatory subunit CK2β.

Journal of molecular biology - 18 Mar 2011

Bischoff Nils, Olsen Birgitte, Raaf Jennifer, Bretner Maria, Issinger Olaf-Georg, Niefind Karsten

Abstract excerpt

Protein kinase CK2 (formerly "casein kinase 2") is composed of a central dimer of noncatalytic subunits (CK2β) binding two catalytic subunits. In humans, there are two isoforms of the catalytic subunit (and an additional splicing variant), one of which (CK2α) is well characterized. To supplement the limited biochemical knowledge about the second paralog (CK2α'), we developed a well-soluble catalytically active...

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Identifiers

PMID: 21241709
DOI: 10.1016/j.jmb.2011.01.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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