Article
Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter.
Oncogene - 8 Jul 2004
Yokota Tomoya, Matsuzaki Youichirou, Miyazawa Kazuhiro, Zindy Frederique, Roussel Martine F, Sakai Toshiyuki
Abstract excerpt
Histone deacetylase (HDAC) inhibitors are known to arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin-dependent kinase inhibitor, p21(WAF1/Cip1). However, several studies have suggested the existence of a p21(WAF1/Cip1)-independent molecular pathway. We report here that HDAC inhibitors activate a member of the INK4 family, the INK4d gene, causing G1 phase arrest, in the human T...
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