Article
Sp1 is involved in the transcriptional activation of p16(INK4) by p21(Waf1) in HeLa cells.
FEBS letters - 23 Apr 2004
Xue Lixiang, Wu Junfeng, Zheng Wenjie, Wang Peichang, Li Jun, Zhang Zongyu, Tong Tanjun
Abstract excerpt
Both p16(INK4) and p21(Waf1) are very important negative regulators of the cell cycle. In this study we examined the effects of p21(Waf1) on the transcription of p16(INK4). We determined that p21(Waf1) can activate the transcription of p16(INK4), and that this effect is GC-box dependent. We also found that the transcription factor Sp1 plays a key role in this event. Upregulation of Sp1 contributes to the...
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