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Article

p15<sup>INK4b</sup> in HDAC inhibitor‐induced growth arrest

21 Oct 2003

Abstract excerpt

Histone deacetylase (HDAC) inhibitors arrest human tumor cells at the G1 phase of the cell cycle and activate the cyclin-dependent kinase inhibitor, p21(WAF1/Cip1). However, several studies have suggested the existence of a p21(WAF1/Cip1)-independent molecular pathway. We report here that HDAC inhibitors, trichostatin A (TSA) and sodium butyrate, activate the p15(INK4b) gene, a member of the INK4 gene family,...

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PMID: 14623092
DOI: 10.1016/s0014-5793(03)01186-4

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