Article
Histone H3 acetylation is associated with reduced p21(WAF1/CIP1) expression by gastric carcinoma.
The Journal of pathology - 1 Jan 2005
Mitani Yoshitsugu, Oue Naohide, Hamai Yoichi, Aung Phyu Phyu, Matsumura Shunji, Nakayama Hirofumi, Kamata Nobuyuki, Yasui Wataru
Abstract excerpt
Histone acetylation appears to play an important role in transcriptional regulation. Inactivation of chromatin by histone deacetylation is involved in the transcriptional repression of several tumour suppressor genes, including p21(WAF1/CIP1). However, the in vivo status of histone acetylation in human cancers, including gastric carcinoma, is not well understood. This study shows that histone H3 in the...
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