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Article

Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter.

Molecular and cellular biology - 1 Jun 2003

Zhu Wei-Guo, Srinivasan Kanur, Dai Zunyan, Duan Wenrui, Druhan Lawrence J, Ding Haiming, Yee Lisa, Villalona-Calero Miguel A, Plass Christoph, Otterson Gregory A

Abstract excerpt

DNA methylation in the promoter of certain genes is associated with transcriptional silencing. Methylation affects gene expression directly by interfering with transcription factor binding and/or indirectly by recruiting histone deacetylases through methyl-DNA-binding proteins. In this study, we demonstrate that the human lung cancer cell line H719 lacks p53-dependent and -independent p21(Cip1) expression. p53...

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Identifiers

PMID: 12773551
DOI: 10.1128/MCB.23.12.4056-4065.2003
PMCID: PMC156121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Methylation of adjacent CpG sites affects Sp1/Sp3 binding and activity in the p21(Cip1) promoter.PMID 12773551Read ↗

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