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Article

The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.

Molecular and cellular biology - 1 Mar 2010

Zupkovitz Gordin, Grausenburger Reinhard, Brunmeir Reinhard, Senese Silvia, Tischler Julia, Jurkin Jennifer, Rembold Martina, Meunier Dominique, Egger Gerda, Lagger Sabine, Chiocca Susanna, Propst Fritz, Weitzer Georg, Seiser Christian

Abstract excerpt

Histone deacetylases (HDACs) are chromatin-modifying enzymes that are involved in the regulation of proliferation, differentiation and development. HDAC inhibitors induce cell cycle arrest, differentiation, or apoptosis in tumor cells and are therefore promising antitumor agents. Numerous genes w...

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Source

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Identifiers

PMID: 20028735
DOI: 10.1128/MCB.01500-09
PMCID: PMC2820891

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-20028735-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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The cyclin-dependent kinase inhibitor p21 is a crucial target for histone deacetylase 1 as a regulator of cellular proliferation.PMID 20028735Read ↗

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient miceSemantic proximity Read ↗

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CDK1 Inhibition Targets the p53-NOXA-MCL1 Axis, Selectively Kills Embryonic Stem Cells, and Prevents Teratoma FormationSemantic proximity Read ↗

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