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Article

Human Rap1 modulates TRF2 attraction to telomeric DNA

11 Feb 2015

Abstract excerpt

More than two decades of genetic research have identified and assigned main biological functions of shelterin proteins that safeguard telomeres. However, a molecular mechanism of how each protein subunit contributes to the protecting function of the whole shelterin complex remains elusive. Human Repressor activator protein 1 (Rap1) forms a multifunctional complex with Telomeric Repeat binding Factor 2 (TRF2)....

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Share to Advanced biosensing and bioanalysis techniques
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25675958
DOI: 10.1093/nar/gkv097

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Related research

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Research trail→

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Human Rap1 modulates TRF2 attraction to telomeric DNAPMID 25675958Read ↗

A higher-order entity formed by the flexible assembly of RAP1 with TRF2Semantic proximity Read ↗

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the TelomereSemantic proximity Read ↗

How the human telomeric proteins TRF1 and TRF2 recognize telomeric DNA: a view from high‐resolution crystal structuresSemantic proximity Read ↗

A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms.Semantic proximity Read ↗

Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivitySemantic proximity Read ↗

TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusionsSemantic proximity Read ↗

A RAP1/TRF2 Complex Inhibits Nonhomologous End-Joining at Human Telomeric DNA EndsSemantic proximity Read ↗

Structure of the TRFH Dimerization Domain of the Human Telomeric Proteins TRF1 and TRF2Semantic proximity Read ↗

TRF2-Mediated Control of Telomere DNA Topology as a Mechanism for Chromosome-End Protection.Semantic proximity Read ↗

Design of High-Affinity Stapled Peptides To Target the Repressor Activator Protein 1 (RAP1)/Telomeric Repeat-Binding Factor 2 (TRF2) Protein-Protein Interaction in the Shelterin Complex.Semantic proximity Read ↗

Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damageSemantic proximity Read ↗

The Intra- and Extra-Telomeric Role of TRF2 in the DNA Damage ResponseSemantic proximity Read ↗

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