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Article

Human Rap1 Interacts Directly with Telomeric DNA and Regulates TRF2 Localization at the Telomere

22 Oct 2012

Abstract excerpt

The TRF2-Rap1 complex suppresses non-homologous end joining and interacts with DNAPK-C to prevent end joining. We previously demonstrated that hTRF2 is a double strand telomere binding protein that forms t-loops in vitro and recognizes three- and four-way junctions independent of DNA sequence. How the DNA binding characteristics of hTRF2 to DNA is altered in the presence of hRap1 however is not known. Here we...

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Share to Advanced biosensing and bioanalysis techniques
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

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PMID: 23086976
DOI: 10.1074/jbc.m112.415984

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