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Article

Somatic activation of oncogenic <i>Kras</i> in hematopoietic cells initiates a rapidly fatal myeloproliferative disorder

29 Dec 2003

Abstract excerpt

RAS mutations are common in myeloid malignancies; however, it is not known whether oncogenic RAS can initiate leukemia. We show that expressing mutant K-Ras(G12D) protein from the endogenous murine locus rapidly induces a fatal myeloproliferative disorder with 100% penetrance characterized by tissue infiltration, hypersensitivity to growth factors, and hyperproliferation. Hematopoietic cells from diseased mice...

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Identifiers

PMID: 14699048
DOI: 10.1073/pnas.0307203101

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Source receipt: pubmed, retrieved 7 Sept 2026.

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