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Article

Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele.

PloS one - 1 Jan 2012

Wang Zuoyun, Feng Yan, Bardeesy Nabeel, Bardessy Nabeel, Wong Kwok-Kin, Liu Xin-Yuan, Ji Hongbin

Abstract excerpt

Animal models which allow the temporal regulation of gene activities are valuable for dissecting gene function in tumorigenesis. Here we have constructed a conditional inducible estrogen receptor-K-ras(G12D) (ER-K-ras(G12D)) knock-in mice allele that allows us to temporally switch on or off the activity of K-ras oncogenic mutant through tamoxifen administration. In vitro studies using mice embryonic fibroblast...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22606359
DOI: 10.1371/journal.pone.0037308
PMCID: PMC3350485

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