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Article

Endogenous K-ras signaling in erythroid differentiation.

Cell cycle (Georgetown, Tex.) - 15 Aug 2007

Zhang Jing, Lodish Harvey F

Abstract excerpt

K-ras is one of the most frequently mutated genes in virtually all types of human cancers. Using mouse fetal liver erythroid progenitors as a model system, we studied the role of endogenous K-ras signaling in erythroid differentiation. When oncogenic K-ras is expressed from its endogenous promoter, it hyperactivates cytokine-dependent signaling pathways and results in a partial block in erythroid differentiation....

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Identifiers

PMID: 17721087
DOI: 10.4161/cc.6.16.4577

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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