Article
Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.
American journal of human genetics - 1 Aug 2005
Oliveira Sofia A, Li Yi-Ju, Noureddine Maher A, Zuchner Stephan, Qin Xuejun, Pericak-Vance Margaret A, Vance Jeffery M
Abstract excerpt
We previously reported a linkage region on chromosome 1p (LOD = 3.41) for genes controlling age at onset (AAO) in Parkinson disease (PD). This region overlaps with the previously reported PARK10 locus. To identify the gene(s) associated with AAO and risk of PD in this region, we first applied a genomic convergence approach that combined gene expression and linkage data. No significant results were found. Second,...
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