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Article

Transition nuclear proteins are required for normal chromatin condensation and functional sperm development.

Genesis (New York, N.Y. : 2000) - 1 Apr 2004

Zhao Ming, Shirley Cynthia R, Hayashi Shotaro, Marcon Ludovic, Mohapatra Bhagyalaxmi, Suganuma Ryota, Behringer Richard R, Boissonneault Guylain, Yanagimachi Ryuzo, Meistrich Marvin L

Abstract excerpt

The histone-to-protamine transition is important in the formation of spermatozoa. In mammals this involves two steps: replacement of histones by transition nuclear proteins (TPs) and replacement of TPs by protamines. To determine the functions of the TPs and their importance for sperm development, we generated mice lacking both TPs, since mice lacking only TP1 or TP2 were fertile. Our results indicated that TP1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15083521
DOI: 10.1002/gene.20019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transition nuclear proteins are required for normal chromatin condensation and functional sperm development.PMID 15083521Read ↗

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