Article
Targeted disruption of the transition protein 2 gene affects sperm chromatin structure and reduces fertility in mice.
Molecular and cellular biology - 1 Nov 2001
Zhao M, Shirley C R, Yu Y E, Mohapatra B, Zhang Y, Unni E, Deng J M, Arango N A, Terry N H, Weil M M, Russell L D, Behringer R R, Meistrich M L
Abstract excerpt
During mammalian spermiogenesis, major restructuring of chromatin takes place. In the mouse, the histones are replaced by the transition proteins, TP1 and TP2, which are in turn replaced by the protamines, P1 and P2. To investigate the role of TP2, we generated mice with a targeted deletion of its gene, Tnp2. Spermatogenesis in Tnp2 null mice was almost normal, with testis weights and epididymal sperm counts...
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