Article

Male mice heterozygous for Protamine-1 and Protamine-2 are infertile displaying sperm damage and retention of Protamine-2 precursors, transition proteins and histones

2026-03-16

Abstract excerpt

<h4>BACKGROUND</h4> During spermiogenesis, histones are exchanged by protamines ( PRMs ) in spermatids, which results in DNA hypercondensation and protection. Rodents and primates express two PRMs ( PRM1 and PRM2 ) in a species-specific ratio. Maintaining this ratio is necessary for functional chromatin reorganization and alteration is associated with sub- or infertility in mice and humans. Prm1 and Prm2 de...

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Literature Corpus work: a01ea9dc-ee80-50cb-99c2-f5c20b9953c2
DOI: 10.64898/2026.03.15.711850

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Male mice heterozygous for Protamine-1 and Protamine-2 are infertile displaying sperm damage and retention of Protamine-2 precursors, transition proteins and histonesDOI 10.64898/2026.03.15.711850Read

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