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Article

Direct visualization of pre-protamine 2 detects protamine assembly failures and predicts ICSI success

1 Feb 2022

Abstract excerpt

Histone-to-protamine transition is an essential step in the generation of fully functional spermatozoa in various mammalian species. In human and mouse, one of the two protamine-encoding genes produces a precursor pre-protamine 2 (pre-PRM2) protein, which is then processed and assembled. Here, we design an original approach based on the generation of pre-PRM2-specific antibodies to visualize the unprocessed...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 35150275
DOI: 10.1093/molehr/gaac004

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