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Article

Teratozoospermia in mice lacking the transition protein 2 (Tnp2)

1 Jun 2001

Abstract excerpt

It is believed that the transition proteins (Tnp1 and Tnp2) participate in the removal of the nucleohistones and in the initial condensation of the spermatid nucleus. Later in spermatogenesis, Tnp1 and Tnp2 are replaced by the protamines 1 and 2. In an effort to elucidate the physiological role of Tnp2, we have disrupted its locus by homologous recombination. Breeding of the Tnp2(-/-) males on different genetic...

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PMID: 11385107
DOI: 10.1093/molehr/7.6.513

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