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Article

An increase in mitochondrial DNA promotes nuclear DNA replication in yeast.

PLoS genetics - 11 Apr 2008

Blank Heidi M, Li Chonghua, Mueller John E, Bogomolnaya Lydia M, Bryk Mary, Polymenis Michael

Abstract excerpt

Coordination between cellular metabolism and DNA replication determines when cells initiate division. It has been assumed that metabolism only plays a permissive role in cell division. While blocking metabolism arrests cell division, it is not known whether an up-regulation of metabolic reactions accelerates cell cycle transitions. Here, we show that increasing the amount of mitochondrial DNA accelerates overall...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18404213
DOI: 10.1371/journal.pgen.1000047
PMCID: PMC2289842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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