Article
An ARS element inhibits DNA replication through a SIR2-dependent mechanism.
Molecular cell - 25 Apr 2008
Crampton Amber, Chang FuJung, Pappas Donald L, Frisch Ryan L, Weinreich Michael
Abstract excerpt
During G1 phase, a prereplicative complex (pre-RC) that determines where DNA synthesis initiates forms at origins. The Sir2p histone deacetylase inhibits pre-RC assembly at a subset of origins, suggesting that Sir2p inhibits DNA replication through a unique aspect of origin structure. Here, we identified five SIR2-sensitive origins on chromosomes III and VI. Linker scan analysis of two origins indicated that they...
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