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Article

Persistent Acetylation of Histone H3 Lysine 56 Compromises the Activity of DNA Replication Origins.

Molecular and cellular biology - 1 Jan 2023

Tremblay Roch, Mehrjoo Yosra, Ahmed Oumaima, Simoneau Antoine, McQuaid Mary E, Affar El Bachir, Nislow Corey, Giaever Guri, Wurtele Hugo

Abstract excerpt

In Saccharomyces cerevisiae, newly synthesized histones H3 are acetylated on lysine 56 (H3 K56ac) by the Rtt109 acetyltransferase prior to their deposition on nascent DNA behind replication forks. Two deacetylases of the sirtuin family, Hst3 and Hst4, remove H3 K56ac from chromatin after S phase. hst3Δ hst4Δ cells present constitutive H3 K56ac, which sensitizes cells to replicative stress via unclear mechanisms....

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Source

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Identifiers

PMID: 37811746
DOI: 10.1080/10985549.2023.2259739
PMCID: PMC10791153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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