Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.

doi:10.1073/pnas.0900190106

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Article

Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.

Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009

Dulev Stanimir, de Renty Christelle, Mehta Rajvi, Minkov Ivan, Schwob Etienne, Strunnikov Alexander

Abstract excerpt

The CDC14 family of multifunctional evolutionarily conserved phosphatases includes major regulators of mitosis in eukaryotes and of DNA damage response in humans. The CDC14 function is also crucial for accurate chromosome segregation, which is exemplified by its absolute requirement in yeast for the anaphase segregation of nucleolar organizers; however the nature of this essential pathway is not understood. Upon...

Topics

Active Transport, Cell Nucleus
Anaphase
Blotting, Western
Cell Cycle Proteins
Cell Nucleus
Chromatin Immunoprecipitation
Chromosome Segregation
Chromosomes, Fungal
DNA Damage
DNA Replication

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA, Fungal

DNA, Ribosomal

G1 Phase

Genes, Essential

Genome, Fungal

Genome-Wide Association Study

Models, Biological

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 19666479
DOI: 10.1073/pnas.0900190106
PMCID: PMC2723162

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Essential global role of CDC14 in DNA synthesis revealed by chromosome underreplication unrecognized by checkpoints in cdc14 mutants.PMID 19666479Read ↗

Anaphase onset before complete DNA replication with intact checkpoint responses.Semantic proximity Read ↗

DNA replication is completed in Saccharomyces cerevisiae cells that lack functional Cdc14, a dual-specificity protein phosphatase.Semantic proximity Read ↗

Novel role for Cdc14 sequestration: Cdc14 dephosphorylates factors that promote DNA replication.Semantic proximity Read ↗

CDK inactivation is the only essential function of the APC/C and the mitotic exit network proteins for origin resetting during mitosis.Semantic proximity Read ↗

The NAD(+)-dependent Sir2p histone deacetylase is a negative regulator of chromosomal DNA replication.Semantic proximity Read ↗

Cleavage and polyadenylation factor, Rna14 is an essential protein required for the maintenance of genomic integrity in fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

The role of DNA replication in chromosome condensation.Semantic proximity Read ↗

Kinetochores and the checkpoint mechanism that monitors for defects in the chromosome segregation machinery.Semantic proximity Read ↗

The Cdk/cDc14 module controls activation of the Yen1 holliday junction resolvase to promote genome stability.Semantic proximity Read ↗

Nucleolar segregation lags behind the rest of the genome and requires Cdc14p activation by the FEAR network.Semantic proximity Read ↗

Mitotic CDK promotes replisome disassembly, fork breakage, and complex DNA rearrangementsSemantic proximity Read ↗

CDC16 controls initiation at chromosome replication origins.Semantic proximity Read ↗

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