Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host factors impacting the innate response in humans to the candidate adjuvants RC529 and monophosphoryl lipid A.

Vaccine - 29 Mar 2004

Tiberio Lorrie, Fletcher Leah, Eldridge John H, Duncan David D

Abstract excerpt

The aim of this study was to determine if certain genotypes might be associated with variable responses to the candidate vaccine adjuvants RC529 and monophosphoryl lipid A (MPL), as well as to bacterial LPS, a structurally similar control stimulus. In this study, the +896 TLR4 polymorphism and se...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Enzyme-Linked Immunosorbent Assay
Share to Lipid A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipopolysaccharides

Share to Receptors, Cell Surface

Share to Sex Characteristics

Share to Toll-Like Receptor 4

Share to Toll-Like Receptors

Source

Identifiers

PMID: 15063577
DOI: 10.1016/j.vaccine.2003.10.019

Genes

TLR4
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15063577-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host factors impacting the innate response in humans to the candidate adjuvants RC529 and monophosphoryl lipid A.PMID 15063577Read ↗

Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.Semantic proximity Read ↗

The role of Toll-like receptor 4 polymorphisms in vaccine immune response.Semantic proximity Read ↗

LPS-mediated production of pro/anti-inflammatory cytokines and eicosanoids in whole blood samples: biological effects of +896A/G TLR4 polymorphism in a Sicilian population of healthy subjects.Semantic proximity Read ↗

Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beings.Semantic proximity Read ↗

The role of TLR4 in endotoxin responsiveness in humans.Semantic proximity Read ↗

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.Semantic proximity Read ↗

Sexual dimorphism in innate immunity.Semantic proximity Read ↗

Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism.Semantic proximity Read ↗

Lipopolysaccharide-induced immune responses in relation to the TLR4(Asp299Gly) gene polymorphism.Semantic proximity Read ↗

Role of TLR4 polymorphisms in inflammatory responses: implications for unsuccessful aging.Semantic proximity Read ↗

Effects of gender, cytokine gene polymorphisms and environmental factors on inflammatory responses.Semantic proximity Read ↗

Effect of Holstein genotype on ex-vivo cytokine response to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) during the periparturient period.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.