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Effect of Holstein genotype on ex-vivo cytokine response to lipopolysaccharide (LPS) and lipoteichoic acid (LTA) during the periparturient period.

Veterinary immunology and immunopathology - 1 Sept 2022

Brink Amber A, Weber Wanda J, Lippolis John D, Cole John B, Godden Sandra M, Seykora Anthony, Crooker Brian A

Abstract excerpt

Effects of Holstein genotype on innate immune response were assessed with ex-vivo lipopolysaccharide (LPS) and lipoteichoic acid (LTA) stimulation of whole blood from unselected (UH, n = 10) and contemporary (CH, n = 11) Holsteins that differ in production by more than 4,500 kg/lactation. Blood was collected at -14, 7, 28, and 49 days in milk (DIM), mixed with a pathogen-associated molecular pattern (PAMP)...

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PMID: 35878562
DOI: 10.1016/j.vetimm.2022.110463

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