Article
Differential activation of human TLR4 by Escherichia coli and Shigella flexneri 2a lipopolysaccharide: combined effects of lipid A acylation state and TLR4 polymorphisms on signaling.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008
Rallabhandi Prasad, Awomoyi Agnes, Thomas Karen E, Phalipon Armelle, Fujimoto Yukari, Fukase Koichi, Kusumoto Shoichi, Qureshi Nilofer, Sztein Marcelo B, Vogel Stefanie N
Abstract excerpt
The lipid A of LPS activates TLR4 through an interaction with myeloid differentiation protein-2 (MD-2) and the degree of lipid A acylation affects TLR4 responsiveness. Two TLR4 single nucleotide polymorphisms (Asp299Gly and Thr399Ile) have been associated with LPS hyporesponsiveness. We hypothesized that the combination of hypoacylation and these single nucleotide polymorphisms would exhibit a compounded effect...
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