Article
TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.
Nature genetics - 1 Jun 2000
Arbour N C, Lorenz E, Schutte B C, Zabner J, Kline J N, Jones M, Frees K, Watt J L, Schwartz D A
Abstract excerpt
There is much variability between individuals in the response to inhaled toxins, but it is not known why certain people develop disease when challenged with environmental agents and others remain healthy. To address this, we investigated whether TLR4 (encoding the toll-like receptor-4), which has been shown to affect lipopolysaccharide (LPS) responsiveness in mice, underlies the variability in airway...
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