Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism.

Cytokine - 7 Jun 2005

van der Graaf Chantal, Kullberg Bart Jan, Joosten Leo, Verver-Jansen Trees, Jacobs Liesbeth, Van der Meer Jos W M, Netea Mihai G

Abstract excerpt

Toll-like receptor-4 (TLR4) is a pattern-recognition receptor not only for exogenous ligands such as lipopolysaccharide (LPS) of Gram-negative bacteria, but also for endogenous ligands such as fibronectin, heat shock proteins and hyaluronan oligosaccharides. The Asp299Gly allele of the TLR4 gene has been associated with increased risk for severe infections, but reduced progression of atherosclerosis. We have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspartic Acid
Share to Chaperonin 60
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Glycoproteins

Share to Polymorphism, Genetic

Share to Receptors, Cell Surface

Share to Toll-Like Receptor 4

Share to Toll-Like Receptors

Source

Identifiers

PMID: 15927851
DOI: 10.1016/j.cyto.2005.02.001

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional consequences of the Asp299Gly Toll-like receptor-4 polymorphism.PMID 15927851Read ↗

Monocytes heterozygous for the Asp299Gly and Thr399Ile mutations in the Toll-like receptor 4 gene show no deficit in lipopolysaccharide signalling.Semantic proximity Read ↗

A functional polymorphism of toll-like receptor 4 is not associated with likelihood or severity of meningococcal disease.Semantic proximity Read ↗

Lipopolysaccharide-induced immune responses in relation to the TLR4(Asp299Gly) gene polymorphism.Semantic proximity Read ↗

Association of the ASP299GLY TLR4 polymorphism with COPD.Semantic proximity Read ↗

The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome.Semantic proximity Read ↗

The TLR4 +896 polymorphism is not associated with lipopolysaccharide hypo-responsiveness in leukocytes.Semantic proximity Read ↗

Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis.Semantic proximity Read ↗

IL-10 release requires stronger toll-like receptor 4-triggering than TNF: a possible explanation for the selective effects of heterozygous TLR4 polymorphism Asp(299)Gly on IL-10 release.Semantic proximity Read ↗

The toll-like receptor 4 Asp299Gly variant: no influence on LPS responsiveness or susceptibility to pulmonary tuberculosis in The Gambia.Semantic proximity Read ↗

Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock.Semantic proximity Read ↗

Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles.Semantic proximity Read ↗

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.