Article
Expression of activation-induced cytidine deaminase (AID) in Burkitt lymphoma cells: rare AID-negative cell lines with the unmutated rearranged VH gene.
Leukemia & lymphoma - 1 Jan 2004
Hardianti Mardiah Suci, Tatsumi Eiji, Syampurnawati Meilani, Furuta Kaho, Saigo Katsuyasu, Kawano Seiji, Kumagai Shunichi, Nakamura Fumihiko, Matsuo Yoshinobu
Abstract excerpt
Activation-induced cytidine deaminase (AID) is an enzyme that catalyzes somatic hypermutation (SHM) and class switch recombination (CSR) of the immunoglobulin (Ig) gene. The expression of AID was reported to be confined to the germinal center (GC). Burkitt lymphoma (BL) cells are regarded as being derived from GC cells. BL cells have been reported to have SHM in the Ig gene with variety in terms of degree,...
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