Article
Only truncated, not complete cytochrome p450 2D6 RNA transcript and no detectable enzyme activity are expressed in human lymphocytes.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2003
McConnachie Lisa A, Phillips Brian, Bajpai Manoj, Shen Danny D, Ho Rodney J Y
Abstract excerpt
Genotyping of the highly polymorphic cytochrome p450 2D6 (CYP2D6) permits a gross classification of individual phenotype (viz. ultra-rapid, extensive, and poor metabolizers). It does not, however, provide a precise prediction of CYP2D6 activity, particularly in an individual possessing at least one functional CYP2D6 allele. It has been suggested that the level of mRNA expression or enzyme activity in lymphocytes,...
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