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Article

Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population.

Journal of medical genetics - 1 Apr 2004

Relton C L, Wilding C S, Pearce M S, Laffling A J, Jonas P A, Lynch S A, Tawn E J, Burn J

Abstract excerpt

OBJECTIVE: To investigate the contribution of polymorphic variation in genes involved in the folate-dependent homocysteine pathway in the aetiology of neural tube defects (NTD). DESIGN: Case-control association study. SUBJECTS: A total of 530 individuals from families affected by NTD, 645 maternal controls, and 602 healthy newborn controls from the northern UK. MAIN OUTCOME MEASURES: Seven polymorphisms in six...

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Source

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Identifiers

PMID: 15060097
DOI: 10.1136/jmg.2003.010694
PMCID: PMC1735724

Genes

MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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