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Article

Maternal and infant gene-folate interactions and the risk of neural tube defects.

American journal of medical genetics. Part A - 1 Oct 2012

Etheredge Analee J, Finnell Richard H, Carmichael Suzan L, Lammer Edward J, Zhu Huiping, Mitchell Laura E, Shaw Gary M

Abstract excerpt

Neural tube defects (NTDs) are common, serious malformations with a complex etiology that suggests involvement of both genetic and environmental factors. The authors evaluated maternal or offspring folate-related gene variants and interactions between the gene variants and maternal intake of folates on the risk of NTDs in their offspring. A case-control study was conducted on mothers and/or their fetuses and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Maternal Nutritional Physiological Phenomena

Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

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Source

Open in PubMed Open full text

Identifiers

PMID: 22903727
DOI: 10.1002/ajmg.a.35552
PMCID: PMC3448841

Genes

SHMT1
TYMS
MTHFD1
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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