Article
Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.
Environmental health perspectives - 1 Oct 2006
Boyles Abee L, Billups Ashley V, Deak Kristen L, Siegel Deborah G, Mehltretter Lorraine, Slifer Susan H, Bassuk Alexander G, Kessler John A, Reed Michael C, Nijhout H Frederik, George Timothy M, Enterline David S, Gilbert John R, Speer Marcy C
Abstract excerpt
BACKGROUND: Folate metabolism pathway genes have been examined for association with neural tube defects (NTDs) because folic acid supplementation reduces the risk of this debilitating birth defect. Most studies addressed these genes individually, often with different populations providing conflicting results. OBJECTIVES: Our study evaluates several folate pathway genes for association with human NTDs,...
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