Article
Mice heterozygous for Atp10c, a putative amphipath, represent a novel model of obesity and type 2 diabetes.
The Journal of nutrition - 1 Apr 2004
Dhar Madhu S, Sommardahl Carla S, Kirkland Tanisa, Nelson Sarah, Donnell Robert, Johnson Dabney K, Castellani Lawrence W
Abstract excerpt
Atp10c is a novel type IV P-type ATPase and is a putative phospholipid transporter. The purpose of this study was to assess the overall effect of the heterozygous deletion of Atp10c on obesity-related phenotypes and metabolic abnormalities in mice fed a high-fat diet. Heterozygous mice with maternal inheritance of Atp10c were compared with heterozygous mice with paternal inheritance of Atp10c and wild-type...
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