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Article

Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age.

Age (Dordrecht, Netherlands) - 1 Jun 2015

Hill Cristal M, Arum Oge, Boparai Ravneet K, Wang Feiya, Fang Yimin, Sun Liou Y, Masternak Michal M, Bartke Andrzej

Abstract excerpt

Longevity and aging are influenced by common intracellular signals of the insulin/insulin-like growth factor (IGF)-1 pathway. Abnormally high levels of bioactive IGF-1 increase the development of various cancers and may contribute to metabolic diseases such as insulin resistance. Enhanced availability of IGF-1 is promoted by cleavage of IGF binding proteins (IGFBPs) by proteases, including the...

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Source

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Identifiers

PMID: 25953669
DOI: 10.1007/s11357-015-9765-1
PMCID: PMC4424199

Genes

TNF
PAPPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Female PAPP-A knockout mice are resistant to metabolic dysfunction induced by high-fat/high-sucrose feeding at middle age.PMID 25953669Read ↗

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