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Article

The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.

Nature immunology - 1 May 2011

Siggs Owen M, Arnold Carrie N, Huber Christoph, Pirie Elaine, Xia Yu, Lin Pei, Nemazee David, Beutler Bruce

Abstract excerpt

B lymphopoiesis begins in the fetal liver, switching after birth to the bone marrow, where it persists for life. The unique developmental outcomes of each phase are well documented, yet their molecular requirements are not. Here we describe two allelic X-linked mutations in mice that caused cell-intrinsic arrest of adult B lymphopoiesis. Mutant fetal liver progenitors generated B cells in situ but not in...

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Identifiers

PMID: 21423172
DOI: 10.1038/ni.2012
PMCID: PMC3079768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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