Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse.

doi:10.1093/oxfordjournals.jhered.a111019

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Article

Fat (fat) and tubby (tub): two autosomal recessive mutations causing obesity syndromes in the mouse.

The Journal of heredity - 1 Jan 2000

Coleman D L, Eicher E M

Abstract excerpt

This report describes the development of obesity syndromes in mice caused by two autosomal recessive mutations, fat (fat), located on chromosome 8, and tubby (tub), located on chromosome 7. Both mutations cause slowly developing but ultimately severe obesity conditions. Although hyperinsulinemia,...

Topics

Aging
Animals
Blood Glucose
Chromosome Mapping
Crosses, Genetic
Diabetes Mellitus, Experimental
Female
Genes, Recessive
Insulin
Male
Mice
Mice, Hairless
Mice, Inbred C57BL
Mutation
Obesity
Pancreas
Syndrome

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