Article
Knockout of the abetalipoproteinemia gene in mice: reduced lipoprotein secretion in heterozygotes and embryonic lethality in homozygotes.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Raabe M, Flynn L M, Zlot C H, Wong J S, Véniant M M, Hamilton R L, Young S G
Abstract excerpt
Abetalipoproteinemia, an inherited human disease characterized by a near-complete absence of the apolipoprotein (apo) B-containing lipoproteins in the plasma, is caused by mutations in the gene for microsomal triglyceride transfer protein (MTP). We used gene targeting to knock out the mouse MTP gene (Mttp). In heterozygous knockout mice (Mttp+/- ), the MTP mRNA, protein, and activity levels were reduced by 50%,...
Topics
- Abetalipoproteinemia
- Alleles
- Animals
- Base Sequence
- Carrier Proteins
- Cells, Cultured
- Embryonic and Fetal Development
- Gene Expression Regulation, Developmental
- Genes, Lethal
- Heterozygote